Los Robles Hospital spokeswoman Kris Carraway-Bowman told the Associated Press that she was discharged around 5 p.m. Friday.
The hospital said earlier that Locklear was medically stable and being cared for in an intensive care unit.
The 50-year-old "Melrose Place" actress was taken to the hospital in Thousand Oaks from her home in Westlake Village, 35 miles northwest of Los Angeles, on Thursday.
Locklear has been hospitalized several times over the years. In 2009, she pleaded no contest to reckless driving after being arrested on suspicion of driving under the influence of prescription medication.
Locklear also starred in such TV series as "Dynasty" and "T.J. Hooker."
