It happened Saturday afternoon near the Bridge Street entrance of the highway.
Initial reports indicate that the car flipped over the guardrail and fell onto Aramingo Avenue.
A 22-year-old male was ejected from the vehicle. He was taken to Temple University Hospital in serious but stable condition.
An 18-year-old female was also taken to the hospital in stable condition.
Authorities say I-95 remains open.
Pennsylvania State Police are currently investigating.
