Reading Police said they were called to the 300 block of Pear Street for a report of a fight around 11:50 pm Friday.
Police said shortly after they were called out for the fight incident, it was also reported that shots were fired in the area.
Geovanie Collazo-Rosa, 23, was pronounced dead at the scene.
Officials said Efrain Lopez-Collazo, 51, was declared dead at Reading Hospital. A third person was transported to a local hospital, according to police.
There's no word on any arrests in the deadly shooting.
Reading Police and detectives are continuing to investigate.