Santorum's campaign says the former senator will stay in Pennsylvania with 3-year-old Bella, who has a genetic condition known as Trisomy 18. The condition typically proves fatal and Santorum often says his daughter wasn't expected to live past 12 months.
Spokesman Hogan Gidley says Santorum hopes to return to a campaign schedule soon.
Santorum canceled his appearance on NBC's "Meet the Press" and a stop at a Miami church.
Santorum is sending his 20-year-old daughter Elizabeth to Sarasota and Punta Gorda for campaign appearances on later Sunday.
Florida's presidential primary is on Tuesday.