Iguodala, who turned 28 on Saturday, received a nice ovation from the crowd when he secured his triple-double with a defensive rebound with 7:34 remaining.
Lou Williams scored 17 points, Elton Brand added 14 and Jrue Holiday had 13 for the Sixers, who improved to 14-6 and 10-2 at home. They are 3-1 on this seven-game homestand, which gets markedly tougher next week with visits from the Orlando Magic on Monday, Chicago Bulls on Wednesday and Miami Heat on Friday.
The Sixers have been a strong second-half team this season, and this game was no different. They came out of halftime with a quick 8-2 run - highlighted by 3-pointers from Iguodala and Jodie Meeks - and extended their lead to 50-33.
Detroit never got closer than nine the rest of the game.
The Pistons received a boost with the return of forward Tayshaun Prince, who had missed the previous two games tending to a family matter. Prince finished with just six points. The short-handed Pistons were still without injured guards Will Bynum and Ben Gordon, as well as forward Charlie Villanueva.
The missing pieces were noticeable as the Pistons struggled mightily on offense in the first half with 31 points, their second-fewest in any half this season. Maybe it was a carryover from Friday's 107-101 overtime loss to the Atlanta Hawks in which the Pistons relinquished a six-point lead in the final 54 seconds of regulation.
One night later, they trailed Philadelphia 42-31 at halftime.
Detroit wasn't much sharper in the second half and fell to 4-17 with four straight losses and eight of nine.
Greg Monroe led the Pistons with 16 points and 10 rebounds, while Austin Daye added 12 points.
Notes: Sixers C Spencer Hawes missed his sixth consecutive game with a strained left Achilles, while rookie F Nikola Vucevic was out for the fourth straight game with a left knee quad strain. ... Monroe was whistled for a technical foul with 1:08 left in the first half. ... The Sixers were 9 for 15 from 3-point territory. ... Sixers coach Doug Collins, on his bobblehead promotion Saturday night: "I like the gray hair. It has wisdom written all over it."