The accident involving a daycare bus and another vehicle occurred just after 3:00 p.m. at 11th and Lombard streets.
Initial reports say three adults and a 4-year-old girl suffered minor injuries.
The adults were transported to Christiana Hospital and the child was taken to A.I. Dupont Hospital.
Two of the injured were on the bus.
The bus was transporting children from Ribbons and Bows Daycare in Wilmington.