The flames broke out in a house on Lois Drive around 1 a.m. Monday.
911 operators reported hearing explosions on the line when the call for the fire came in to the dispatch center.
Heavy fire and smoke poured from the second floor of the home when firefighters arrived.
They knocked down the blaze in about an hour.
The four victims are being treated at the hospital for burns and smoke inhalation.
There's no word on their conditions.
