The local Newspaper Guild says 21 people are taking buyouts and 19 full- and part-time editorial workers will be laid off by March 31.
Meanwhile, workers await word on their next owner. A group of local powerbrokers and philanthropists hopes to buy the company from New York hedge funds.
The guild issued a sharply worded memo Thursday that attacks Publisher Greg Osberg's leadership.
The memo accuses Osberg of withholding all or parts of stories on the company's sale and faltering with the launch of a newspaper-sponsored tablet computer, among other complaints.
Osberg didn't immediately return a message. A newspaper spokesman says he hasn't seen the memo.