DeJuan Blair added 19 points for the Spurs, who won for the seventh time in eight games and swept the season series with the 76ers despite being without Tim Duncan. With the Spurs playing three games in three nights, coach Gregg Popovich gave the 35-year-old Duncan his second day off this season.
Philadelphia lost for the second time in its last four games as it played without Andre Iguodala, who was out due to left patella tendonitis.
San Antonio improved to 24-1 at home against the 76ers since the start of the 1986-87 season, winning the last eight. The 76ers' last win in San Antonio was in 2004.
Manu Ginobili and Kawhi Leonard had 11 points and 10 rebounds as the Spurs won their third game in three nights while missing one of their three stars in each game. Parker sat out with a hamstring injury Friday at home against the Mavericks and Ginobili missed the win at New Orleans on Saturday with a hip injury.
Elton Brand led the 76ers with 12 points. Jodie Meeks, starting for Iguodala, added 11 points. Evan Turner and Jrue Holiday each added 10.
Philadelphia trailed by three points at halftime, but San Antonio's defense helped force 14 second-half turnovers.
Before the game, Popovich had said that Boris Diaw, playing in only his third game for the Spurs, would start for Duncan. But Diaw came off the bench and Matt Bonner drew the start. Bonner helped San Antonio get off to a strong start with eight points in the first quarter, including two 3-pointers. He finished with 10 points, and Danny Green also had 10 to help the Spurs improve to 20-4 at home.
San Antonio led 52-49 at halftime behind Parker's 11 points and four assists. Blair had 10 points on 5-of-6 shooting. Holliday led the 76ers with 10 points in the first half.
After the Spurs had taken a 29-22 lead into the second quarter, the 76ers went on a 12-0 run to go in front. But San Antonio responded with a 10-0 run of its own.
NOTES: Duncan, sitting with the Spurs' bench, was called for a technical foul with 2:35 remaining. Joey Crawford had warned the teams earlier about arguing calls, and Josh Tiven issued the technical. Crawford ejected Duncan from a 2007 game for laughing, and the referee later was suspended. Duncan was on the bench at the time he was ejected. ... Spurs G Gary Neal (left mid-foot sprain) and F Tiago Splitter (mid-back spasms) didn't play. It was the second straight game that Neal has missed and third for Splitter.