Winfrey went to the jail in Orangeburg last week where 30-year-old Shaquan Duley is awaiting sentencing.
Winfrey interviewed Duley's family in September 2010, a month after Duley suffocated her 2-year-old and 18-month-old sons, then tried to stage their deaths by driving her car into a river. Prosecutors say she killed the children after being badgered by her mother about being a poor parent.
Duley faces 30 years to life in prison when she's sentenced Friday.
The interview will air at 9 p.m. on April 1 as part of "Oprah's Next Chapter" on the Oprah Winfrey Network.
