Pennsylvania State Police say 38-year-old Nicole M. Sloan, of Philadelphia, died as a result of the crash at 8:45 a.m. under the Spruce Street overpass.
According to investigators, a total of six vehicles were involved, including Sloan's 2010 Honda Accord, a tanker truck and a box truck.
Police say traffic was stopped in the left lane when a Freightliner box truck, driven by 40-year-old Anthony Taylor of Chester, failed to stop and hit Sloan's Honda.
That crash pushed Sloan's car into the right lane where it was hit by a tanker truck driven by 55-year-old James Gills of Blackwood, New Jersey.
Sloan was pronounced dead at Hahnemann University Hospital.
I-95 southbound was closed for several hours following the crash.
There has been no word on any charges so far as this investigation continues.