It happened around 4:30 a.m. Sunday at the 40/40 Club on the 2100 block of Atlantic Avenue.
Officers were called several times with the report of a fight.
Authorities say the brawl began after 31-year-old Tony L. Wilson - a 40/40 Club patron - refused a security screening and then assaulted a security officer.
Police Officer Michael Francisco, who was working at the club while off-duty, tried to help subdue the man, but the patron sprayed him with a chemical substance.
Several fights then broke out near the club as other police officers arrived.
Two men soon started fighting with Officer Brent Dooley, who was hit in the head by a liquor bottle.
One of the men also choked a police dog who tried to subdue him.
Both officers and the police dog are expected to fully recover.
