The crash happened around 1:00 p.m. in the southbound lanes near mile marker 21.3 in Deptford, Gloucester County.
At least one person was trapped in a vehicle.
The view from Chopper 6 HD showed one tractor trailer with heavy front end damage, while a car had heavy damage to the rear.
There was no word yet on the severity of the injuries.
The crash blocked all lanes for more than 2 hours. The accident has since been cleared.