Tyheem Melton, 43, of the 6400 block of Race Street is wanted for the early Friday violence inside the Corral Bar.
The two killed were identified as Troy Wimberly, 38, of the 4900 block of Chestnut Street and Crystal Shadding, 43, of the 7100 block of Theodore Street.
They were shot around 1:40 a.m. inside the bar in the 5200 block of Market Street.
Wimberly was rushed to the hospital but pronounced dead a short time later. Shadding was pronounced dead at the scene.
There was no immediate word on the motive as the investigation continues.
Anyone with information is asked contact the Philadelphia Police Department at 215-686-TIPS (8477) or at phillypolice.com.