On Wednesday, police released a picture of the car 29-year-old Kareem El was driving when he was shot and killed early Sunday morning.
Police are looking for anyone who may have seen that car before the killing as the investigation continues.
The crime happened just before 3:00am Sunday morning in the eastbound lanes near the Montgomery Drive exit.
Police say the suspects drove up beside El's vehicle and fired multiple shots.
El was shot at least one time in the head.
Officials say the victim's car continued to travel on the Schuylkill Expressway for sometime after he was hit and later crashed into the center median.
A passing officer was flagged down by a passenger inside the vehicle. Medics arrived and El was pronounced dead a short time later.
Authorities say it appears El was targeted.
Anyone with information is asked to contact police at 215-560-6200.