It happened around 2:00 p.m. Friday along the 200 block of Airport Road at Allegretto Drive.
The victim was ejected from his vehicle and suffered severe head injuries. He was pronounced dead at the scene.
The driver of the other car was taken to Christiana Hospital for serious but non-life threatening injuries.
State Police quickly closed Airport Road in both directions but all lanes reopened around 4:00 p.m.
No word what sparked the crash.