The accident happened just after 7:00 a.m. on the northbound lanes of I-95 near Leigh Avenue.
Police say a 41-year-old woman was injured in the crash. She was transported to the hospital with minor injuries.
So far, there is no word on if any children were on the bus at the time of the crash.
The accident scene has been cleared, but residual delays are still being felt along I-95.