Numerous 911 calls came in at 2:49 a.m. and police were dispatched to the 300 block of Rose Street.
Once there, officers found the victims in two separate locations, both with gunshot wounds to the upper torso area.
Both victims were transported to Crozer Chester Medical Center.
Their identities, and conditions, have not been released.
Anyone with information is asked to contact Chester Police Detective Division (610) 447-7908.