The fire broke out shortly after 7:30 p.m. along the 900 block of Bayview Road in Odessa.
It took fire crews a half hour to get the upper hand on the blaze.
When crews searched the home, they discovered one of the occupants had succumbed to the fire.
No details of the victim have been released.
Officials say a dog also perished in the fire.
There is no word yet on a cause.