The accident happened around 5:10 a.m. in the southbound lanes between I-95 and Philadelphia Pike.
Police say a tire blew on the truck causing the driver, 34-year-old Vincent Dixon of Newark, Del., to lose control.
The truck hit the cement barrier, rupturing a fuel tank. The fuel leaked onto a piece of wooden debris on the highway, which caught fire.
The fire was quickly extinguished and Dixon was not injured.
I-495 southbound between the I-95 split and Philadelphia Pike was closed for approximately four hours as the crash was investigated and cleared.