Officials say the fire broke out at a home on North 6th Street.
Daniel Ortiz and Hector Carreras were in the area, heard a little girl scream 'fire,' and saw smoke coming from a residence.
Carreras rescued a 4-year-old girl, Ortiz rescued a baby.
The kids and the rescuers were unhurt.
Officials say the children were left alone and those responsible could face charges.