The accident happened at 3:30 p.m. Tuesday near Route 54 and Jackson Road.
Police say it appears one vehicle crossed the center line and collided with another.
Police tell Action News three women were in the first vehicle and that all suffered injuries.
Two of the women were airlifted right away to area hospitals. A third, the driver, was trapped in the vehicle for about an hour and a half.
The woman was reportedly alert and conscious as crews worked to free her. She was finally freed and airlifted to a nearby hospital.
There was no immediate word on any of the women's conditions.
Authorities say the female driver of other vehicle was taken to the hospital to be checked out.
Her injuries were not believed to be life-threatening.