The incident happened around 3:50 a.m. in the 5400 block of Chester Avenue.
When crews arrived they found a 29 year old man suffering from multiple stab wounds to the back and arm.
The incident was first reported as a break-in with the suspect being stabbed, however police say it was a domestic dispute.
A wife stabbed her estranged husband with a beer bottle.
She was taken into custody and her husband remains at the Hospital of the University of Pennsylvania in stable condition.
The couple has not been identified.