The crash happened just before noon at the intersection of Route 45 and Monroeville Road in South Harrison Township.
Authorities say the tractor trailer, carrying roof trusses on a flatbed trailer, was traveling north on Route 45 when it struck the pickup truck broadside at the Monroeville Road intersection.
The pickup was traveling eastbound on Monroeville Road. The driver was transported to Cooper Medical Center with non-life-threatening injuries.
The collision sparked a fire in the cab of the tractor trailer. The truck driver died at the scene of the crash.
An autopsy is scheduled for Wednesday.
Names of the drivers are being withheld pending notification of their families.
So far no charges have been filed in the case.