The accident happened around 10:30 Saturday night on the South Concourse Drive near Belmont Avenue.
Police say a minivan plowed into an SUV and the impact sent the SUV rolling over.
The driver of the minivan, her 6-month-old, a 2-year-old and another adult were inside at the time.
The children were taken to Children's Hospital of Philadelphia and the two adults were taken to the hospital of the University of Pennsylvania for minor injuries.
An elderly couple - inside the SUV - suffered minor bumps and bruises as well.
Meanwhile the mother who was behind the wheel faces driving under the influence charges. No word on her identity.