The robbery happened at The First Niagara Bank at 364 Main Street in Collegeville.
According to investigators, the man entered the bank at 11:35 a.m. and gave the teller a demand note, which indicated he had a gun.
The teller handed over and undisclosed amount of cash and the man fled the bank on foot, last seen heading east on Main Street.
The suspect is described as a white male in his late 20's, 5'6" tall, wearing glasses, a Flyers baseball cap, a green polo shirt, and capri-style jeans.
Anyone with information is asked to call the Collegeville Police Department or the FBI AT 215-418-4000.
There may be a reward for information leading to this subject's capture, and tipsters can remain anonymous.