Yvonne Scott, 58, of the 6500 block of North Gratz Street, was a passenger in the car involved. She was also the aunt of the driver, 31-year-old Saria Scott-Jarrett.
It happened just after 6:00 p.m. Monday along the 6100 block of Old York Road near Sparks Street.
Witness Maurice Bowman tells Action News he was traveling southbound on Old York Road just before the accident when he noticed the woman in an Acura traveling northbound swerve into his lane.
"She was coming down, she was kind of in my lane so I swerved out the way and I looked in my rearview mirror and she just ran into the bus," Bowman said.
Officials say Scott-Jarrett taken to Albert Einstein Medical Center where she is in critical condition.
Yvonne Scott was pronounced dead at the scene.
Police say 11 people onboard the bus, including the bus driver, were injured. All 11 were taken to three area hospitals where they were treated and released.
Authorities tell Action News they are looking into the possibility that Scott-Jarrett was under the influence.
"There was strong odor of alcohol coming from the Acura, it also had open containers of alcohol inside of that vehicle," Small said.
Police say the bus is equipped with interior and exterior cameras which caught the incident, but it is up to SEPTA to decide whether or not to release the video.
Meanwhile, on Tuesday, family members were still reeling from Scott's death.
"She would give anybody anything. She had a good heart and I love her and I'm going to miss her so very much," said Scott's daughter, Yolonda Frank.