The accident happened just before 4:00 a.m. Thursday in the southbound lanes of the interstate near Route 896.
Investigators say the driver of a box truck carrying linens collided with the rear of a tractor-trailer.
The driver of the box truck was pronounced dead at the scene.
There is no word at this time on what led to the accident.
I-95 southbound was closed at Route 896 for nearly eight hours, finally re-opening at 11:45 a.m.
