Police say the incident began as an altercation in Elkton, Maryland involving a gun.
When Maryland State Police arrived to the initial scene, officials say the suspects' vehicle rammed the state police vehicle before fleeing the scene.
Maryland State Police gave chase of the vehicle onto I-95 into Delaware.
The chase went about 30 miles before coming to a grinding halt after Delaware State Police applied stop sticks causing the vehicle's tires to flatten.
The fleeing vehicle crashed and two suspects, a man and woman, were apprehended.
A third male fled on foot into the marshes and is being sought by state police.