Edward was born in Denver by a gestational surrogate Wednesday night. He weighed 7 pounds and 4 ounces.
The couple were in the delivery room for the four-hour labor and birth.
Giuliana Rancic is a red-carpet fixture and host of E! News. Bill, who cut the baby's umbilical cord, is an entrepreneur and motivational speaker. He was the first-season winner on TV's "The Apprentice." The couple star in the Style Network reality show "Giuliana & Bill" that dealt with their fertility issues.
Giuliana Rancic tells E! News that she and her husband are "so in love with the little guy already!"
Edward arrived just in time for his parents' fifth wedding anniversary on Saturday.