The crash happened just after midnight at the intersection of 20th Street and Belfield Avenue.
Police say two juveniles, one male and one female, carjacked the owner of a Toyota Avalon at gunpoint.
Officers were engaged in a pursuit of the stolen car when it crashed head-on into a Mazda. Another car, a Cadillac then rear-ended the Mazda.
At least 5 people were injured, including the two suspects.
They were all taken to area hospitals and listed in stable condition.
The teen suspects are facing a variety of charges.