The crash happened around 8:55 a.m. in the 2000 block of Bethlehem Pike.
Police say they arrived to find two vehicles blocking the roadway. Those vehicles sustained heavy damage.
A third vehicle, with minor damage, was stopped in a nearby driveway.
One person pronounced dead at the scene while another was flown to the hospital.
The names of those involved are being withheld by police pending notification of family.
The cause of the crash remains under investigation.