It happened at 3:30 p.m. Thursday at a home in the 100 block of Ridgeland Road.
Emergency responders say the man, believed to be about 50 years old, fell from a ladder while working on his home, then suffered a heart attack.
Medics performed CPR on the man as he was taken to Carrcroft Elementary School, then airlifted by a state police helicopter to Christiana Hospital.
There is no word on his condition.