The couple married Saturday evening during a ceremony with friends and family at Front Porch Farms about 40 miles outside Nashville.
The marriage means all four members of the Followill family band are off the market. Older brothers Nathan and Caleb and cousin Matthew have already started families.
The 25-year-old Followill and 21-year-old Patterson were engaged last spring. Patterson wore a white dress with lace bodice and flowing feathered skirt by Monique Lhuillier and Followill wore black Gucci.
Patterson said in a Tweet earlier Saturday she's "marrying my best friend." Followill quipped that he's "dreamed about this day since I was a little girl."