It happened around 1:40 Sunday afternoon in the area of 32nd and Arizona streets.
Initial reports indicate that a man in his 20s was shot multiple times by an unknown assailant on a bike.
The victim was struck in the abdomen and torso. He was taken to Temple University Hospital where he was later pronounced dead.
The shooter was spotted wearing a red hooded sweatshirt in the area of 32nd and Cumberland streets.
Police believe he may have taken the sweatshirt off and is now wearing a grey t-shirt.
Anyone with information about the shooting is asked to contact Philadelphia Police at 215-686-TIPS, text a tip to PPDTIP (773847) or through phillypolice.com.