The accident happened at approx 3:15 p.m.
Officials say an SUV crossed over from the southbound lanes of I-95 into the northbound lane striking a car head-on.
The 24-year-old driver of the SUV was trapped in his vehicle and had to be extricated by the fire department.
He was rushed to Christiana Hospital with serious injuries.
The 20-year old driver of the other car suffered injuries to her chest, head and extremities. She was also transported to Christiana Hospital where she is listed in stable condition.
The accident remains under investigation.
