The man, identified by SPCA officials as Robert Rochester, 55, of New Castle, died on Wednesday night. It is not yet known if his death was directly related to the attack.
Police previously said he had been seriously injured.
The attack happened around 4:15 p.m. Friday in the area of Argonne Avenue and Main Street in Stanton, Delaware.
Delaware State Police responded to the report of two people bitten. A state trooper arrived and found two dogs attacking a smaller dog.
The officer fired his weapon at the animals, ending the attack. One dog, a German Shepherd, was shot and wounded.
Police say Rochester was attacked by the German Shepherd before the incident and suffered multiple wounds from dog bites.
A 51-year-old woman suffered a dog bite to her upper body but refused treatment at the scene.
Both dogs involved in the attack were taken by the Kent County SPCA and provided with veterinary care. The dog that was attacked remained with its owner.
The owner of the attacking dogs, who has not been named, was charged with having a vicious dog unrestrained, and faces a fine, and also stipulations on keeping the dogs if found guilty.
There has been no word on any further charges as this investigation continues.