The accident happened at 8:55 p.m. at East High Street and Sunnyside Avenue.
Police say the teen, identified as Tim Paciello, was walking across High Street and was hit while standing in a turning lane.
Paciello was flown to Hahnemann University Hospital where he was pronounced dead.
An autopsy is planned by the Philadelphia Medical Examiner's Office.
The Montgomery County D.A. said the driver of the striking vehicle is a 43-year-old Collegeville woman, who was cooperative with police. She stayed on the scene and voluntarily provided blood, the D.A. said.
The Superintendent of Pottsgrove High School was notified of the accident last night and assembled a crisis team, the D.A. said. Grief counselors are available for the students.