This year's theme is "Everyone Loves Quitters."
And now, there are more ways than ever to quit - 7 drugs have government approval.
But while medication is important, adding in counseling dramatically raises the chances for success.
In fact, the best way to quit is a combination of medication and counseling.
We know, it is not easy. The average smoker tries quitting 3 to 5 times before he or she stops. But it's worth the effort.
Thomas Glynn, of the American Cancer Society, says, "Never give up, because it's going to add 10 years to your life. It's going to save you a lot of money and it's going to enable you to play with your children and grandchildren."
The benefits of quitting start mounting almost immediately.
"Within 12 hours, your blood pressure is down, you blood will flow more freely. You can breath more easily," says Glynn.
After 3 months, your risk of 15 different smoking-related cancers drops.
And the benefits continue adding up.
"A lot of smokers they describe it as, 'I just feel better. I can taste my food, I can climb stairs,' he says.
And at one year, you are half as likely to develop heart disease, and much less likely to go back to smoking.