It happened around 11:00 Friday morning on the 1400 block of South 53rd Street.
Police say when the female victim answered the door, two men armed with guns made their way inside.
The woman was forced into the basement while one of the men went upstairs.
One shot was fired and both suspects fled the scene.
The female victim went upstairs and discovered her husband shot in the leg.
He was taken to the Hospital of the University of Pennsylvania for what appeared to be non-life threatening injuries.
No word on motive or a description of the suspects.