The incident took place just after 7:00 p.m. at 58th and Master streets.
Police say a basketball game was about to commence inside the center when two men, believed to be in their late teens to early 20s, began to argue.
That argument escalated into a fight that was broken up by officers on site.
The two were ushered out of the facility and not long after, shots rang out on the street.
Police say a 19-year-old man was shot multiple times in the stomach and both legs.
He was taken to the Hospital of the University of Pennsylvania, where he later died.
Police made an arrest about a block away.