It happened around 10:30 Saturday night at the University Court Apartments.
Authorities say three men dressed in black clothes with dark-colored scullies forced their way in and opened fire.
One victim - in his 20s - was shot multiple times and pronounced dead at the scene.
Another male - also in his 20s - was shot multiple times and taken to the Hospital of the University of Pennsylvania in critical condition.
The third victim - a teenager - was hit in the chest and the face and was taken in critical condition to HUP.
The suspects fled the scene. Anyone with information is asked to contact Philadelphia Police at 215-686-TIPS (8477), text a tip to PPD TIP (773847) or through phillypolice.com.