Police say two cars collided head-on along Churchman's Road near Iroquois Court in Christiana just after 10:30 p.m.
Police say 37-year-old Robert L. Vanaskey, Jr. of New Castle, Delaware was travelling westbound in a Pontiac Grand-Am when he crossed the road into the eastbound lanes and struck a Honda Accord driven by 24-year-old Melissa L. Foraker of New Castle.
Both drivers were trapped and had to be extricated from their cars.
Police say Foraker was not properly restrained and was pronounced dead at the scene.
Vanaskey was rushed to Christiana Hospital and is listed in critical condition.
Churchman's Road was closed for two-and-a-half hours while the accident was cleared.
Police continue to investigate.