Police say the suspect was fleeing Maryland State Police heading north on I-95.
The chase ended in New Castle County, Delaware when he crashed into a car parked on the shoulder of northbound I-495 in Claymont.
Police say the suspect's car flipped several times.
The suspect was flown to Christiana Hospital. There is no word on his condition.
Northbound I-495 was shut down during the investigation and cleanup.