It happened around 1:15 Friday morning on the 200 block of Meng Road in Lower Frederick Township.
Authorities say heavy flames were showing from the 2nd floor of the home upon arrival.
Surrounding fire companies responded to the scene. Extra water tankers were also brought in to assist with battling the blaze.
Fire crews were able to get the flames under control within an hour.
No injuries were reported.
Officials are still investigating what sparked the blaze.