It happened around 11:15 Friday evening on the 3600 block of Richmond Street.
Officers responded to the scene after the report of a weapon.
The 52-year-old victim was found with a stab wound to the chest. He was taken to Hahnemann Hospital in critical condition.
Police arrested the victim's girlfriend, 53-year-old Lorraine Smith, at the scene.
She faces a number of assault charges and related offenses.
A motive for the stabbing has not been released.