It happened at 9:30 a.m. Thursday at New Falls Road and Route 413 in Levittown.
Police say the driver of a pickup truck swerved to avoid a bicyclist and slammed into the side of The Video Store on New Falls Road.
Images from Chopper 6 HD showed a large hole in the side of what appeared to be a cinder block storage area attached to the rear of the main building.
One person was taken to an area hospital in stable condition.
A police investigation is underway.