Officials say the pursuit began in Kennett Square.
The chase continued into Delaware around 4:00 p.m. Saturday.
Near 9th and Market streets, police say four suspects bailed out of the car and fled.
One of the men was apprehended near 7th and Walnut. The other three suspects remain at large.
The men are wanted for an alleged home invasion in Chester County.
The suspects' names have not been released.