The one car crash happened around 3:30 a.m. when police say the driver of the vehicle lost control and slammed into a tree on the school's property.
The impact of the crash trapped all four of the students inside of the car.
Firefighters worked for approximately 15 minutes to free the students.
Two of the students were taken by ambulance to Abington Memorial Hospital in critical condition.
Two other students were taken by ambulance to Abington Health-Lansdale Campus with minor injuries.