The flames broke out around 4:30 a.m. on the 4600 block of Larchwood Avenue in a converted apartment building.
Crews arrived to fire showing on the first and second floors of the property.
Fire officials say a 48-year-old woman jumped from a second story window to escape the flames.
She suffered burns over 70-percent of her body and was taken to the Hospital of the University of Pennsylvania where she is listed in serious but stable condition.
The fire marshal is on the scene investigating the cause of the blaze.
So far, there are no reports of other injuries.